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Read more about the causes of Addison’s disease Treating Addison's diseaseĪddison’s disease is treated with medication to replace the missing hormones. Other potential causes include conditions that can damage the adrenal glands, such as tuberculosis (TB), although this is uncommon in the UK. It's not clear why this happens, but it's responsible for 70-90% of cases in the UK. The condition is usually the result of a problem with the immune system, which causes it to attack the outer layer of the adrenal gland (the adrenal cortex), disrupting the production of steroid hormones aldosterone and cortisol. Read more about the symptoms of Addison’s disease and diagnosing Addison’s disease Why it happens You may also develop small areas of darkened skin, or darkened lips or gums.Īlthough these symptoms aren’t always caused by Addison’s disease, you should see your GP, so they can be investigated. Over time, these problems may become more severe and you may experience further symptoms, such as dizziness, fainting, cramps and exhaustion. loss of appetite and unintentional weight loss.It can affect people of any age, although it's most common between the ages of 30 and 50. It's also more common in women than men.Įarly-stage symptoms of Addison’s disease are similar to other more common health conditions, such as depression or flu. You may experience:

In Addison's disease, the adrenal gland is damaged, and not enough cortisol and aldosterone are produced.Ībout 8,400 people in the UK have Addison's disease. They produce essential hormones: cortisol, aldosterone and adrenaline. The adrenal glands are two small glands that sit on top of the kidneys. Addison’s disease (also known as primary adrenal insufficiency or hypoadrenalism) is a rare disorder of the adrenal glands.